The upregulated DEGs showed various enforced transcription factors’ networks including IRF3, TAL1, JUN, and FOXA (Fig. 4A), whereas the downregulated DEGs demonstrated dramatic network suppression of E2F1, a cell cycle progressor [29, 30], and NR2C2, a cancer-promoting orphan receptor [31–33] (Supplementary Fig. 8A). Here, E2F1 is linked to cancer.