In conclusion, our results demonstrate that (1) age-related changes in global cognitive function may be accelerated in ADAD mutation carriers who are also APOE e4+ compared to those who are APOE e4−; (2) age-related changes in global cognitive function may be delayed in ADAD mutation carriers who are also APOE e2+ compared to those who are APOE e2−; and (3) higher educational attainment may have a protective effect against cognitive impairment, even in the presence of strong genetic risk factors. Here, APOE is linked to Cognitive impairment.