On the other hand, MGL-mediated engagement of DCs with GalNAc-containing ligands can enhance DC cell activation and survival by activation of MAPK/ERK and NF-kappaB signalling, resulting in an increase of CD8+ T cell mediating anti-tumour response [66] and secretion of IL-10 and TNF-α by DCs [67]. This evidence concerns the gene CD8A and neoplasm.