IL-6 has anti-tumorigenic properties in the form of priming effector T-cells25; and unchecked IFN-γ could compromise the colonic epithelial barrier26,38 allowing an influx of microbiota that could influence cancer progression despite IL-6 being described as pro-tumorigenic, and IFN-γ being protective in CRC26,27. Here, IL6 is linked to cancer.