Thus, PA activated Rac1 through CD36-Src-Akt signaling pathway, regulated MMP-9 expression through CD36-Src-Akt/ERK signaling pathway, and then changed the distribution of tubulin, N-WASP, cortactin and Arp2/3 in LUAD cells to trigger actin structural remodeling, and finally promote tumor cells metastasis. This evidence concerns the gene WASL and neoplasm.