Given the evidence that CD36 mediated PA-induced actin remodeling (Fig. 4), we could speculate that PA changed the distribution of MMP-9, tubulin, N-WASP, cortactin and Arp2/3 through CD36-Src-Akt/ERK signaling pathway to trigger actin structural remodeling in LUAD cells, and finally promote the invasion of tumor cells. The gene discussed is MMP9; the disease is neoplasm.