Moreover, in cognitively normal older adults, peripheral insulin resistance, indicated by high Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) scores [12], has been associated with poorer performance on neurocognitive tests and abnormalities in biomarkers of AD, including increases in phosphorylated tau protein in the cerebrospinal fluid (CSF) and lower global cerebral glucose metabolism on positron emission tomography (PET) scans [13-16]. The gene discussed is MAPT; the disease is Alzheimer disease.