INS and Alzheimer disease: The bilateral parietal-occipital junction, middle temporal gyri, temporal lobe generally, and hippocampi were mentioned as regions whose volumes correlated with various brain insulin measures [239, 240, 246]; chronic INL insulin was associated with greater preservation of tissue volumes in a broad range of cortical regions including several frontal, temporal, and parietal regions that have been implicated in the pathological progression of AD [273].