Indeed, Talbot et al were the first to show in post-mortem human AD brain sections from the University of Pennsylvania and Rush University Medical Center cohorts, that BIR was present, defined by the ex vivo response to insulin stimulation, and that levels of pIRS1(S616, S636/639) negatively correlated with cognition [10] (Fig. 2). The gene discussed is KCNJ11; the disease is Alzheimer disease.