Serum levels of TMEM166 (12.54 ± 3.74 ug/mL vs 38.01 ± 10.01 ug/mL, p<0.01), IL-6 (1.02 ± 0.27 pg/mL vs 3.08 ± 0.78 pg/mL, p<0.05) and CRP (1.64 ± 0.6 ng/mL vs 3.09 ± 1.38 ng/mL, p<0.05) after CEA in perioperative stroke patients were statistically higher than in patients within the control group. The gene discussed is IL6; the disease is Stroke.