Kinesin Family member C3 (KIFC3), a kinesin superfamily protein, was upregulated in ESCC tissues and associated with poor prognosis in patients with ESCC, and mechanistic studies indicated that KIFC3 promoted proliferation, migration, and invasion of ESCC via β-catenin signaling and EMT.10 The gene discussed is KIFC3; the disease is esophageal squamous cell carcinoma.