AREG and infection: The tissue remodeling capacity of IL1RL1+ Treg cells has shown to be mediated by the expression of epidermal growth factor receptor (EGFR) ligand amphiregulin (AREG), which promotes the development and homeostasis of various organs, including the mammary, ovary glands, and visceral adipose tissue (VAT), and tissue repair following infection by a myriad of pathogens [reviewed in (25, 26)].