MYO1B and neoplasm: First, in the above cohort of 137 NB specimens, high MYO1B protein expression (i.e., H-scores > 20) as assessed by IHC is associated with increased INRG (International Neuroblastoma Risk Group) risk (P = 0.021; Fig. 4A) and unfavorable tumor histology (P = 0.008; Fig. 4B).