Higher dementia rates were observed in individuals with DS and COVID-19, whencompared with individuals with COVID-19 without DS19,21,38 and individuals with DS and respiratory infections caused by other etiologies.37 Illouz et al.31 described a change in the endocytosis process in individuals with DSrelated to some genes located on chromosome 21, including Amyloid BetaPrecursor Protein (APP), known to mediate dementia in theseindividuals. The gene discussed is APP; the disease is respiratory tract infectious disorder.