APP and COVID-19: Higher dementia rates were observed in individuals with DS and COVID-19, whencompared with individuals with COVID-19 without DS19,21,38 and individuals with DS and respiratory infections caused by other etiologies.37 Illouz et al.31 described a change in the endocytosis process in individuals with DSrelated to some genes located on chromosome 21, including Amyloid BetaPrecursor Protein (APP), known to mediate dementia in theseindividuals.