The ALL cell line MHH-CALL-4 shows a marked increase of annexin V positive cells as well as of caspases 3 and 7 after incubation with Th1 cytokines, whereas Nalm-6 did not undergo apoptosis after treatment with IFN-γ and TNF-α (Fig. 4a, b). This evidence concerns the gene CASP3 and acute lymphoblastic leukemia.