Two of five cases showed mutations in SF3B1, generally associated with favorable prognosis; however, one case (B7), in addition to DNMT3A and CSF3R mutations, also exhibited a prognostically unfavorable ASXL1 mutation and progressed to MDS-IB/EB [3, 38, 39]. This evidence concerns the gene ASXL1 and myelodysplastic syndrome.