Areas in need of exploration include whether there exist any form of genetic susceptibility to lung cancer induced by radon exposure, the possibility of a specific hotspot in certain genes with a role in cell replication (e.g., TP53), and even some association with indoor radon and specific mutations in driver genes (e.g., EGFR) or genes involved in cell growth (e.g., ALK) and, which are a target for lung cancer treatment. This evidence concerns the gene TP53 and lung cancer.