An active, enhanced nucleophagy delays aging in mice and nematodes while a deficient one, due to nesprin‐2 (the ANC‐1 ortholog in C. elegans) impairment for instance, predisposes to tumorigenesis in germline organs, in the same species36; additionally, nesprin‐2 polymorphisms were associated with ovarian cancer and endometrioses in women.37 The gene discussed is SYNE2; the disease is ovarian cancer.