CCL22 and septic shock: Decreased riboflavin levels were also noted in patients using opioids.66 Riboflavin has anti-inflammatory property and its supplementation was shown to inhibit the activation of inflammasome NLRP3,67 protect from LPS-induced septic shock,68 enhance phagocytosis, and limit inflammation.69 Consistently, depletion of riboflavin negatively correlated with several inflammatory response genes such as Tlr2, Il6, Il18, Nlrp12, Ccl22, Cxcr2 and Ccl17.