Decreased riboflavin levels were also noted in patients using opioids.66 Riboflavin has anti-inflammatory property and its supplementation was shown to inhibit the activation of inflammasome NLRP3,67 protect from LPS-induced septic shock,68 enhance phagocytosis, and limit inflammation.69 Consistently, depletion of riboflavin negatively correlated with several inflammatory response genes such as Tlr2, Il6, Il18, Nlrp12, Ccl22, Cxcr2 and Ccl17. Here, IL18 is linked to septic shock.