These common genes are associated with NASH pathogenesis, and include proteins linked to hepatic fibrosis (collagen 1a1; Col1a1, Col1a2 and Col3a1), metabolic syndrome [MetS; galectin 3 (Lgals3), lipoprotein lipase (Lpl), glycoprotein nmb (Gpnmb), fatty acid binding protein-5 (Fabp5), and the acute phase response (Saa1-3)]. The gene discussed is GPNMB; the disease is Hepatic fibrosis.