Ldlr−/− mice fed the WD become obese and develop markers of insulin resistance, i.e., elevated HOMA-IR, dyslipidemia, endotoxinemia and elevated markers of hepatic macrosteatosis, inflammation, fibrosis and hepatic injury [alanine aminotransferase (ALT) and aspartate aminotransferase (AST)] (19, 21, 25). This evidence concerns the gene GPT and Insulin resistance.