While not all changes occurring in the liver transcriptome in response to the WD are related to NASH pathology, many of these genes are indicative of the dysregulated metabolic (Lgals1, Fabp5, Lpl and Hk2) and inflammatory processes (Itgax, Cd68, Sparc and Cyba). This evidence concerns the gene CYBA and metabolic dysfunction-associated steatohepatitis.