Then, the slow increase of BP and sustained HTN, which occur during the next few weeks, is thought to be mediated by neural and humoral factors, including elevated sympathetic tone to resistance arterioles and vasopressin release, respectively.50 We considered that in the model DOCA-salt HTN, the role of PRR in the RVLM is bi-phasic given that RVLM-specific ablation of PRR in the early developmental stage of DOCA-salt HTN is protective, while during the late maintenance stage, seems to be detrimental. The gene discussed is ATP6AP2; the disease is hypertensive disorder.