SFRP2 and myocardial infarction: In myocardial infarct-related studies, inhibition of the Wnt pathway using sFRP1, sFRP2, or sFRP4 was shown to reduce fibrosis and improve cardiac function (Barandon et al., 2011; Fan et al., 2018; He et al., 2010; Laeremans et al., 2011; Matsushima et al., 2010).