Javaheri et al. (2019) noticed that macrophage-specific over-expression of transcription factor EB (M φ-TFEB) expression could improve ventricular function after IR injury, and TFEB in macrophages played a role in ventricular remodeling after MI by mediating the inflammatory response. In this study, we verified that TFEB affected left remodeling after MI, demonstrating that TFEB alleviated infarction extension and protected the systolic function of the heart (Figs. 1C–1F). WGA staining showed that TFEB down-regulation was associated with severe cardiac hypertrophy (Fig. 1G). The gene discussed is TFEB; the disease is cardiac hypertrophy.