EGF and neoplasm: Signals that induce EMT (EGF, HGF, TGF-β, and PDGF) are produced by tumor-associated stroma and are accountable for promoting functional activation in malignment cell of EMT-inducing transcription factors (Snail, Slug, zinc finger E-box bind-ing homeobox 1 (ZEB1), Twist, Goosecoid, and FOXC2) [51].