A recent study utilized the SuStaIn algorithm to establish a data-driven pathological TDP-43 staging system in ALS, FTLD due to TDP-43 proteinopathies (FTLD-TDP), and limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) [28]. Here, TARDBP is linked to amyotrophic lateral sclerosis.