This pathway is involved in the cell cycle, growth and proliferation, and implicated in the progression of various cancers.46 Interestingly, components which have a stimulatory effect on the pathway like RPTOR, MTOR or MYC strongly correlate with each other and also demonstrate a significant anti-correlation to inhibitory factors such as PTEN, TSC1 or TSC2. The gene discussed is MYC; the disease is cancer.