Tetraspanin CD82 (UniProt P40237) is known to regulate oligodendrocyte migration and differentiation (Mela and Goldman, 2009; Mela and Goldman, 2013), and the finding of the InterPro entry IPR018503 Tetraspanin among significantly downregulated terms is in line with the general reduction of oligodendrocyte and myelination-related pathways and provides additional insight in mechanisms of the aberrant white matter development in MLIV. The gene discussed is CD82; the disease is mucolipidosis type IV.