Given the identification of a splicing variant in the SERPINE2 gene, and the thorough targeted re-sequencing analysis already described in patient #156 and additional 22 ROHHAD patients, the whole gene locus was fully analyzed in the dataset of the #203 proband, both with visual inspection of the alignments and with bioinformatics tools, but no variant was identified. This evidence concerns the gene SERPINE2 and rapid-onset childhood obesity-hypothalamic dysfunction-hypoventilation-autonomic dysregulation syndrome.