We therefore decided to screen the whole genomic portion of the SERPINE2 gene by Sanger sequencing and Long-PCR targeted NGS re-sequencing in 22 additional ROHHAD or suspected-ROHHAD patients, made available in the meantime, without finding any pathogenic variant (data not show). The gene discussed is SERPINE2; the disease is rapid-onset childhood obesity-hypothalamic dysfunction-hypoventilation-autonomic dysregulation syndrome.