An interesting study conducted by Zou et al. (2019) showed that blocking meningeal lymphatic drainage in A53T mice, overexpressing mutated form of humanα-synuclein, aggravated glymphatic dysfunction leading to severe Parkinson’s disease-like pathology including severe accumulation of α-syn, glial activation, inflammation, dopaminergic neuronal loss, and motor deficits. The gene discussed is SNCA; the disease is Parkinson disease.