AIM2 and systemic lupus erythematosus: However, aberrant activation of AIM2 can cause immune-related diseases such as systemic lupus erythematosus (SLE) (Panchanathan et al., 2010), psoriasis (Dombrowski et al., 2011), primary Sjögren’s syndrome (Vakrakou et al., 2020), and arthritis (Baum et al., 2015).