SYP and small cell lung carcinoma: To further validate the co-cultured organoid model’s pathophysiological characteristics, we compared the expression of CGRP, Chromogranin A, NCAM and Synaptophysin in the patient SCLC tumor sections (Figure 2A), cell-culture derived xenografts (CDX) tumors (Figure 2B), 2D SCLC cell line cultures (Figure 2C) and in the developed organoid model (Figure 2D) at 14 days of culture.