Cell culture supernatants secreted by both types of SCLC organoid models were collected at 0 DPT and 31 DPT and analyzed for secreted cytokines (interleukin (IL), IL-6, IL-8), chemokines [growth regulated alpha protein (GRO-α), monocyte chemoattractant protein-1 (MCP-1), vascular endothelial growth factor (VEGF-A)], and matrix metalloproteinases (MMP1, MMP2). The gene discussed is MMP1; the disease is small cell lung carcinoma.