Interestingly, the SCLC monoculture organoids cultured in monoculture media showed a trend towards secreting more GRO-α, IL-8, MMP-1 and MMP-2 at DPT 31 than at DPT 0, but to a much smaller extent than the co-cultures, showing that SCLC cells secrete these factors when they survive after chemotherapy, but more so in the presence of ALFs. This evidence concerns the gene MMP1 and small cell lung carcinoma.