Speculatively, eight potential active metabolites, including kaempferol, quercetin, oleanolic acid, ursolic acid, loganin, geniposide, morroniside, cornuside, were implied as key bioactive constituents, EGFR, AKT1, ADCY2, ADCY3, ADCY8, ADCY9, and GCK were possible to be the core targets which played important roles in CF against diabetes. The gene discussed is GCK; the disease is cystic fibrosis.