JAK2 and lung carcinoma: Furthermore, erianin also downregulated the protein expression levels of p-STAT3, p-JAK2, MMP-2, MMP-9, COX-2, HIF-1α, and IL-6, indicating that erianin inhibited angiogenesis of lung cancer cells by targeting JAK2/STAT3 pathway and inhibiting IDO-induced angiogenesis (SU et al., 2017).