Compared to MICT, short-term HIIT (running, 85%–90% maximum power output, 7 sessions) displayed a more substantial effect on the increased IL-10 level (Dorneles et al., 2019) and a concomitant decrease in the IL-8 concentration, a pro-inflammatory factor released from mononuclear cells (Dorneles et al., 2016) in men (aged 20–40 years) with obesity. The gene discussed is CXCL8; the disease is obesity disorder.