Twelve weeks of HIIT (running, 85%–90% maximum aerobic speed, 5 sessions/week) effectively reduced pro-apoptotic proteins, including cytochrome c release, caspase-8, and caspase-3 to suppress cardiomyopathy and HF in rats (3 weeks old) with obesity (Astani et al., 2022). Here, CASP8 is linked to obesity due to melanocortin 4 receptor deficiency.