INS and obesity due to melanocortin 4 receptor deficiency: Only 2 weeks of maximal all-out cycling (3 sessions/week) resulted in a significant decrease in EAT and PAT, along with increased aerobic capacity and insulin sensitivity in men (aged 43–53 years) affected by obesity with defective glucose tolerance (DGT), whereas HIIT appears superior to MICT (Honkala et al., 2017).