Following 12 weeks of high-intensity interval running (100% HRmax, 3 sessions/week), the plasma adiponectin and high-density lipoprotein-C (HDL-C) concentration increased dramatically in adult women (mean age 15.9 years) affected by obesity (Racil et al., 2013). The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.