Among boys (mean age 11.06 years) (Paahoo et al., 2021), girls (mean age 16 years) (Plavsic et al., 2020; Abassi et al., 2021), and women (aged 40–50 years) affected by obesity (Ratajczak et al., 2020), 3 months of HIIT was more effective than aerobic training for decreasing CRP and related cardiovascular risk factors. Here, CRP is linked to obesity due to melanocortin 4 receptor deficiency.