Moreover, HIIT-induced IL-10 overexpression may suppress IL-β, IL-6, and TNF-α in mononuclear cells challenged with lipopolysaccharide and the transcription of IL-8 in polymorphonuclear leukocytes in individuals with obesity (Dorneles et al., 2016; Barry et al., 2018). Here, IL6 is linked to obesity due to melanocortin 4 receptor deficiency.