For instance, 12 weeks of high-intensity interval cycling (70%–100% HRmax, 3 sessions/week) exerted a reduced in fasting plasma glucose (−6.6%), fasting insulin (−47.2%), HOMA-IR (−50%), and systolic blood pressure (−6 mmHg) in women (mean age 33.5 years) affected by obesity with IR (Alvarez et al., 2017). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.