GPT and obesity due to melanocortin 4 receptor deficiency: Twelve weeks of high-intensity interval cycling (85%–95% HRmax, 2 sessions/week) could dramatically decreased alanine aminotransferase (ALT) and increased VO2max in patients (mean age 52.1 years) with obesity and metabolic syndrome (MetS) (Reljic et al., 2021a).