Koichiro et al. showed that colchicine significantly improved survival, left ventricular end-diastolic diameter and LVEF at 4 weeks after MI in mice via attenuating the expression of pro-inflammatory cytokines and NLRP3 inflammasome, and inhibiting neutrophil and macrophage infiltration (36). The gene discussed is NLRP3; the disease is myocardial infarction.