The risk factors for suboptimal response to GnRH agonist trigger had been reported as low or high BMI, low basal LH level or low trigger day LH level, prolonged stimulation, higher gonadotropins dose, long-term use of OCP, and hypogonadotropic hypogonadism (20). This evidence concerns the gene PLOD1 and hypogonadotropic hypogonadism.