Cu, being the key element in activated ceruloplasmin,is known to be essential for oxidizing the pro-oxidative Fe2+ to redox-inactive Fe3+, thus reducing potential ROS generation.Manganese found to be associated with ALS samples (Table 3), in turn, has been provento promote oxidative stress and is implicated in neurodegenerativeconditions.47 Besides, we observed someassociation of Mn species with steroids (Figure 2A) as well as correlations of Mn specieswith sex hormones and other steroids (Figure 2C). The gene discussed is CP; the disease is amyotrophic lateral sclerosis.