TARDBP and amyotrophic lateral sclerosis: Although there are a few human studies on ALS andsteroids, severalshreds of evidence come from different animal models of the disease.In Drosophila models, decreased expression of TDP-43 determined thecytoplasmic accumulations of the ecdysteroid receptor (EcR) and afailure to switch EcR-dependent gene programs from a pupal to adultpattern sustaining the hypothesis that TDP-43 loss of function causesneuronal loss due to defective steroid receptor-mediated gene programswitching in Drosophila melanogaster.