M2 TAMs, which occupy the dominant position in TME, exert their roles on tumour cells by secreting EVs (miR‐21,34 miR‐588,35 lncRNA CRNDE,36 circ 000823537 and ApoE38), proteins (MMP239 and MMP940), various chemokines (CXCL5,41 CXCL842 and CCL843) and reprogramming metabolism, thereby promoting cell proliferation and metastasis, conferring chemoresistance, and ultimately aggravating the progression of GC.44, 45, 46, 47. The gene discussed is CXCL5; the disease is gastric cancer.