Using tissue‐specific OTUB1 knockout mice, we and others have shown that OTUB1 is involved in CNS autoimmunity,31 lupus‐like autoimmunity,33 sepsis,34 liver infection35 and T cell response36 by regulating astrocytes, B cells, dendritic cells, hepatocytes and T cells, respectively. The gene discussed is OTUB1; the disease is Autoimmunity.