Besides, ablation of OTUB1 significantly increased the proliferation and viability of 4T1 cells, while overexpression of CCN6 in OTUB1−/− cells reversed the effect (Figure 5D–F and Figure S10B), suggesting that OTUB1 inhibits breast cancer proliferation and viability by elevating CCN6 levels. The gene discussed is CCN6; the disease is breast carcinoma.