TRPM2 and neoplasm: TRPM2 could sustain tumor cell viability by activating transcription factors such as hypoxia-inducible factor-alpha (HIF-1/2α), cAMP-responsive element-binding protein (CREB), and nuclear factor (erythroid-derived 2)-related factor-2 (Nrf2), subsequently modulating the downstream pathways including mitochondrial function maintenance, ATP production, cell autophagy, DNA repair, cellular bioenergetics, and ROS production [15–20].