Addressing this knowledge gap, we performed longitudinal local field potential (LFP) recordings in a commonly used mouse model of AD, APPswe/PSEN1dE9 (APP/PS1) mice [20], and collected magnetoencephalography (MEG) measurements from pre-symptomatic human subjects carrying APP or PSEN1 mutations causing autosomal dominant familial AD. Here, PSEN1 is linked to Alzheimer disease.