The main results were not materially changed if the models (1) were additionally adjusted for cognitive performance (Supplemental Table S4); (2) were additionally adjusted for APOE ε4 status (Supplemental Figure S3); (3) excluded the incidence of dementia, stroke or PD occurring within two or four years after recruitment (Supplemental Table S5); 4) used a multiple imputation approach to impute the missing covariates (Supplemental Figure S4). Here, APOE is linked to Parkinson disease.