Tumor expression of ER target genes progesterone receptor (PR; Fig. 7C), growth-regulating estrogen receptor binding 1 (GREB1; Fig. 7D), and trefoil factor 1 (TFF1/pS2; Fig. 7E) were all significantly elevated in E2-treated HFD- versus LFD-fed females. This evidence concerns the gene GREB1 and neoplasm.