On the other hand, EPAC has shown to have a pro-metastatic role as it acts by activating ERK pathway and αvβ3 integrin through RAP1 thus promoting tumorigenesis and migration in human lung cancer cells but also by influencing other signalling cascades in cells derived from human metastatic melanomas, in human melanoma samples and melanoma cell lines [85–87]. The gene discussed is MAPK1; the disease is melanoma.