STAMBP and neoplasm: Briefly, α-MSH induces the release of calcium (Ca2+) from endoplasmic reticulum (ER) by a phospholipase C (PLC) dependent mechanism and Ca2+ efflux is connected with the translocation of PPARγ into the nucleus, where it promotes the transcription of target genes involved in lipid metabolism, adipogenesis, maintenance of metabolic homeostasis, inflammation and anticancer effects in a variety of human tumours [45].