ACHE and Alzheimer disease: Additionally, the reference study [36] reported no statistically significant differences between Aβ + AD and HCs in body mass index, arterial hypertension, diabetes mellitus, and rheumatoid arthritis status, while there were statistically significant differences in cognitive function (MMSE) with reduced performance in the Aβ + AD and higher usage of AChE inhibitors and antidepressants in Aβ + AD, as expected [36].