In this regard, it has been demonstrated that the expression of some acute and inflammatory phase proteins, such as interleukin 1 (IL-1), interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), and serum C-reactive protein (CRP) are increased in PCOS patients, with a detrimental effect on ovarian function, ovulation, fertilization and implantation [7]. The gene discussed is TNF; the disease is polycystic ovary syndrome.