We here found an increase in the volume and area of blood vessels in the PCOS and PCOS Sham groups, in agreement with the study of Zaidi and coworkers [59] In our study, increased collagen volume was observed in the PCOS and PCOS Sham groups, thus reinforcing the possible role of TGF-β1 into ovarian tissue capsule fibrosis in PCOS [60]. The gene discussed is TGFB1; the disease is polycystic ovary syndrome.