And higher expression of, LAG3, PDCD1 and TIGIT, and lower expression levels of CD274, HAVCR2 and PDCD1LG2 were found in the ACSL1 low-expression subgroup versus the ACSL1 high-expression subgroup.These results suggest that immune cells-expressed immune checkpoints (LAG3, PDCD1 and TIGIT) may participate in the immune escape of tumor cells in the ACSL1 low-expression subgroup of ccRCC, and ACSL1 low-expression group could be suitable for the combination of LAG3 or TIGIT with PD-1 inhibitors. Here, LAG3 is linked to nonpapillary renal cell carcinoma.