ACE2 and hepatocellular carcinoma: AICAR induces the binding of SIRT1 to the − 15,794 to − 15,656 bp, − 15,621 to − 15,521 bp, and − 15,607 to − 15,505 bp regions in the ACE2 promoter (Fig. 2, Table 1), enhancing ACE2 transcription in the Huh7 hepatoma cells [49].