In a cohort of 20 AD and 15 controls who underwent 18F-flortaucipir, 11C-PiB and FDG-PET, regional tau PET deposition co-localised with hypometabolic regions and correlated with areas critical for cognitive functions uniquely affected in distinct variants of AD (e.g. posterior cortical atrophy) [191]. This evidence concerns the gene MAPT and Alzheimer disease.