The orphan nuclear receptor NR2F1, commonly mutated in cancers [87, 88], was shown to be epigenetically upregulated downstream of TGFb/p38 signalling (Fig. 1b) in murine models of dormancy [85], as well as in DTCs isolated from long-term prostate cancer patients [89, 90]. Here, MAPK1 is linked to Familial prostate cancer.