Indeed, in vitro models using aggregates of squamous carcinoma cells grown in a nutrient-deprived suspension, have been shown to arrest via growth factor-independent epidermal growth factor receptor (EGFR)-Y1086 autophosphorylation, which leads to reduced AKT signalling (Fig. 1b) and reduced CyclinD [35]. Here, EGFR is linked to squamous cell carcinoma.