For example, the expression of EGR1 has been associated with prostate cancer development35, esophageal tumor tissues36, and human gastric cancer progression37; the expression of EGR2 has been associated with the pathogenesis of fibrosis38 and Guillain-Barré Syndrome39; and the expressions of EGR3 and EGR4 has been associated with prostate cancer40 and small cell lung cancer41, respectively. The gene discussed is EGR3; the disease is neoplasm of esophagus.