TP53 and acute myeloid leukemia: These CNAs were not observed in other individuals or genotypes, including heterozygous/mono-allelic TP53-mutated colonies (Fig. 4d), but are a well-recognised feature of transformation to MDS/AML in SDS36 and are consistent with the CNAs that are recognised to be associated with biallelic TP53 mutant clones in cancer more generally37,38.