Accumulated studies have suggested that the plasticity of white adipose tissues and brown adipose tissues determines the individuals’ obese or lean, and UCP1-mediated activation of brown adipose tissue, which tends to be easier for thermogenesis and consumption, has been proposed a new treatment approach for combating obesity and its related diseases [40, 41]. This evidence concerns the gene UCP1 and obesity due to melanocortin 4 receptor deficiency.