Dramatically increased numbers of tdTomato+ Meso-CAR T cells started to infiltrate into both tumor stroma and tumor nest regions, even at day 1 post-second treatment in tumors first treated with FAP-CAR T cells compared with the tumors first treated with MigR control or Meso-CAR T cells (Fig. 7b, c). This evidence concerns the gene CXCR3 and neoplasm.