To compare the behavior of tumor stroma-targeted FAP-CAR T cells with TAA (mesothelin)-targeted CAR T cells, we utilized a second-generation FAP-CAR vector encoding a scFv based on the sequence of the anti-FAP monoclonal antibody 4G5 produced in our laboratory that cross reacts with mouse, human and canine FAP27, and a previously described mouse Meso-CAR designated A0324 (Fig. 1a). The gene discussed is FAP; the disease is neoplasm.