CTLA4 and neoplasm: Although our results, together with previous studies that showed depletion of FAP+-CAFs enhanced the efficacy of anti-cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and programmed cell death ligand 1 (PD-L1) blockade8 and prolonged survival, the response was transient with resumption of tumor growth and demise of all animals in time.