In addition, on day 7, compared with MigR control and Meso-CAR T cells, tumor-infiltrating FAP-CAR T cells expressed lower levels of PD-1 (Fig. 2c), higher levels of Ki-67 (Fig. 2d), and produced higher levels of IFN-γ (Fig. 2e) after isolation and ex vivo stimulation with a cell activation cocktail of PMA and ionomycin, in the presence of Brefeldin A to enhance intracellular accumulation of cytokines. This evidence concerns the gene FAP and neoplasm.