Moreover, a higher number of total T cells accumulated in tumor nests accompanied by significantly decreased expression of PanCK+ tumor cells and depletion of PDPN+ CAFs in the tumors treated with FAP-CAR T cells followed by FAP-CAR and Meso-CAR T cells than in other combinations (Supplementary Figs. 10a, b). The gene discussed is PDPN; the disease is neoplasm.